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Research Articles
Phosphatidylserine (PS)
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Nutr Neurosci 2001;4(3):169-78 |
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The influence of phosphatidylserine
supplementation on mood and heart rate when faced with an acute
stressor.
Benton D, Donohoe RT, Sillance B, Nabb S.
Department of Psychology,
University of Wales Swansea, United Kingdom.
d.benton@swansea.ac.uk
There have been previous reports that supplements of
phosphatidylserine (PS) blunted the release of cortisol in response
to exercise stress and that it improved mood. The present study
extended these observations by considering whether PS
supplementation influenced subjective feelings of stress and the
change in heart rate when a stressful mental arithmetic task was
performed. In young adults, with neuroticism scores above rather
than below the median, the taking of 300mg PS each day for a month
was associated with feeling less stressed and having a better mood.
The study for the first time reports an improvement in mood
following PS supplementation in a sub-group of young healthy adults.
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Isr J Psychiatry Relat Sci 2000;37(4):302-7 |
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An open trial of plant-source derived
phosphatydilserine for treatment of age-related cognitive decline.
Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y,
Lerer B.
Department of Psychiatry C,
Chaim
Sheba Medical Center, and Tel Aviv University Sackler School of
Medicine, Tel Aviv, Israel.
shaulsch@post.tau.ac.il
We assessed whether the efficacy of plant-source derived
phosphatydilserine (one of the phospholipids which play an important
functional role in membrane-related processes in the brain) for
treatment of age related cognitive decline is consistent with
previous (placebo controlled) positive findings with bovine
derivative of PS (BC-PS). Eighteen healthy elderly volunteers
meeting Age Associated Memory Impairment inclusion and exclusion
criteria were treated for 12 weeks with plant-source derived
phosphatydilserine (PS) (100 mg x 3/day p.o.) and evaluated at base
line, after 6 weeks of treatment and at the end of the trial.
Fifteen concluded the study. All but two outcome measures elicited a
significant drug over time effect. Post-hoc paired t-tests showed
that the significant effect was attributable to an improvement from
base line to week 6 and that effect was maintained at week 12. These
results are encouraging. However, they await double-blind controlled
verification in a large sample before suggesting that this may be a
viable approach to the treatment of age-related cognitive decline,
without exposing the patients to possible hazards involved in the
treatment with bovine derivative of PS (BC-PS).
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Eur J Clin Pharmacol 1992;42(4):385-8 |
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Blunting by chronic phosphatidylserine
administration of the stress-induced activation of the hypothalamo-pituitary-adrenal
axis in healthy men.
Monteleone P, Maj M, Beinat L, Natale M, Kemali D.
Institute of
Psychiatry, First Medical School, University of Naples, Italy.
The effect of chronic administration of phosphatidylserine derived
from brain cortex on the neuroendocrine responses to physical stress
has been examined in a placebo-controlled study in 9 healthy men.
Phosphatidylserine 800 mg/d for 10 days significantly blunted the
ACTH and cortisol responses to physical exercise (P = 0.003 and P =
0.03, respectively), without affecting the rise in plasma GH and PRL.
Physical exercise significantly increased the plasma lactate
concentration both after placebo and phosphatidylserine. The results
suggest that chronic oral administration of phosphatidylserine may
counteract stress-induced activation of the hypothalamo-pituitary-adrenal
axis in man.
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Neuroendocrinology 1990 Sep;52(3):243-8 |
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Effects of phosphatidylserine on the
neuroendocrine response to physical stress in humans.
Monteleone P, Beinat L, Tanzillo C, Maj M, Kemali D.
Institute of Medical Psychology and Psychiatry,
First
Medical School, University of Naples, Italy.
The activity of brain cortex-derived phosphatidylserine (BC-PS) on
the neuroendocrine and neurovegetative responses to physical stress
was tested in 8 healthy men who underwent three experiments with a
bicycle ergometer. According to a double-blind design, before
starting the exercise, each subject received intravenously, within
10 min, 50 or 75 mg of BC-PS or a volume-matched placebo diluted in
100 ml of saline. Blood samples were collected before and after the
exercise for plasma epinephrine (E), norepinephrine (NE), dopamine
(DA), adrenocorticotropin (ACTH), cortisol, growth hormone (GH),
prolactin (PRL) and glucose determinations. Blood pressure and heart
rate were also recorded. Physical stress induced a clear-cut
increase in plasma E, NE, ACTH, cortisol, GH and PRL, whereas no
significant change was observed in plasma DA and glucose.
Pretreatment with both 50 and 75 mg BC-PS significantly blunted the
ACTH and cortisol responses to physical stress.
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